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<h1>Molekulardiagnostische Leistungen</h1>
<br><br><br>


<table border=1  cellspacing=0 cellpadding=4  class="text">
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		<td></td>
		<td><h2>Parameter</h2></td>
		<td><h2>Material</h2></td>			
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	<tr bgcolor="CCCCCC">
		<td>1</td>
		<td colspan=2 class="text-grau">Tumor-Diagnostik</td>
	</tr>
	
	<tr>
		<td>1.1</td>
		<td><b>Lymphomdiagnostik</b><br>
			a) Klonale IgH-Umlagerung (B-Zell)<br>
			b) Klonale TCR-Umlagerung (T-Zell)
		</td>
		<td rowspan=5>Paraffin-Schnitte, Frischmaterial,
			Material aus der Zytologie
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		<td>1.2</td>
		<td><b>Mutationen im k-ras-Gen</b>   (Codon 12,13)</td>
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		<td>1.3</td>
		<td><b>B-RAF Mutation (V600)</b></td>
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		<td>1.4</td>
		<td><b>c-kit- / PDGFRA-Mutationen</b><br>
			Identifikation von Mutationen in den Exonen 9, 11, 13 und 17 des c-kit-Gens;<br>
			Identifikation von Mutationen in den Exonen 12 und 18 des PDGFRA-Gens
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		<td>1.5</td>
		<td><b>EGFR-Mutationen</b>   Identifikation von Mutationen der Exone 18, 19, 20 und 21 des EGFR-Gens</td>
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		<td>1.6</td>
		<td><b>Mikrosatelliteninstabilit&auml;t</b><br>
			Molekulare Analytik bei V.a. HNPCC
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		<td>Tumor- und Normalgewebe: Paraffin-Schnitte, Frisch-material, EDTA-Blut</td>
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		<td>1.7</td>
		<td><b>uPA / PAI</b><br>
			Quantitative Bestimmung mittels ELISA
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		<td>Frischmaterial</td>
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		<td>1.8</td>
		<td><b>EndoPredict-Test</b></td>
		<td>Paraffin-Schnitte</td>
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	<tr bgcolor="CCCCCC">
		<td>2</td>
		<td colspan=2 class="text-grau">Abortdiagnostik</td>
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		<td>2.1</td>
		<td><b>Abortdiagnostik</b><br>
			Molekulargenetischer Nachweis von Aneuploidien der Chromosomen 2, 13, 14, 15, 16, 18, 21, 22, X und Y.
		</td>
		<td>Paraffin-Schnitte, Frischmaterial</td>
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	<tr bgcolor="CCCCCC">
		<td>3</td>
		<td colspan=2 class="text-grau">Erreger</td>
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		<td>3.1</td>
		<td><b>HPV</b>    Konsensus-PCR (GP+/My) mit HPV-Typisierung durch Sequenzierung, Papillocheck</td>
		<td rowspan=7>Paraffin-Schnitte, Frischmaterial,<br>
			Material aus der Zytologie
		</td>
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		<td>3.2</td>
		<td><b>CMV</b></td>
	</tr>
		
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		<td>3.3</td>
		<td><b>EBV</b></td>
	</tr>
		
	<tr>
		<td>3.4</td>
		<td><b>Mycobacterium tuberculosis-Komplex</b></td>
	</tr>
		
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		<td>3.5</td>
		<td><b>Atypische Mykobakterien</b><br>
			(M. avium, M. intracellulare)
		</td>
	</tr>
		
	<tr>
		<td>3.6</td>
		<td><b>Toxoplasma gondii</b></td>
	</tr>
		
	<tr>
		<td>3.7</td>
		<td><b>HSV I / II</b></td>
	</tr>
		
	<tr>
		<td>3.8</td>
		<td><b>Chlamydia trachomatis</b></td>
		<td rowspan=2>Paraffin-Schnitte, Frischmaterial<br>
			Material aus der Zytologie
		</td>
	</tr>
		
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		<td>3.9</td>
		<td><b>H. pylori Clarithromycin-Resistenz</b></td>
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	<tr bgcolor="CCCCCC">
		<td>4</td>
		<td colspan=2 class="text-grau">H&auml;matologie</td>
	</tr>
		
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		<td>4.1</td>
		<td><b>Quantitativer Nachweis der bcr/abl Fusionstranskripte</b><br>
		   (Philadelphia-Chromosom) </td>
		<td>EDTA-Blut in Roche-Stabilisierungs-Reagenz</td>
	</tr>
		
	<tr>
		<td>4.2</td>
		<td><b>JAK2 (V617F) Mutation</b><br>
			Myeloproliferative Erkrankungen
		</td>
		<td rowspan=2>EDTA-Blut, Paraffin-Schnitte,<br>
			Knochenmark-Ausstriche
		</td>
	</tr>
		
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		<td>4.3</td>
		<td><b>MPL (W515K/W515L)</b><br>
			Myeloproliferative Erkrankungen
		</td>
	</tr>
		
	<tr bgcolor="CCCCCC">
		<td>5</td>
		<td colspan=2 class="text-grau">Stoffwechselerkrankungen</td>
	</tr>
		
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		<td>5.1</td>
		<td><b>H&auml;mochromatose</b><br>
			Nachweis der Mutationen H63D, S65C, C282Y
		</td>
		<td>EDTA-Blut</td>
	</tr>
		
	<tr bgcolor="CCCCCC">
		<td>6</td>
		<td colspan=2 class="text-grau">Blutgerinnungsst&ouml;rungen</td>
	</tr>
		
	<tr>
		<td>6.1</td>
		<td><b>Protein S</b><br>
			Sequenzierung der codierenden Bereiche 
		</td>
		<td rowspan=12>EDTA-Blut</td>
	</tr>
		
	<tr>
		<td>6.2</td>
		<td><b>Protein C</b><br>
			Sequenzierung der codierenden Bereiche
		</td>
	</tr>
		
	<tr>
		<td>6.3</td>
		<td><b>Faktor VII</b><br>
			Sequenzierung der codierenden Bereiche
		</td>
	</tr>
		
	<tr>
		<td>6.4</td>
		<td><b>Antithrombin III</b><br>
			Sequenzierung der codierenden Bereiche
		</td>
	</tr>
		
	<tr>
		<td>6.5</td>
		<td><b>Faktor V-Leiden</b>   G1691A</td>
	</tr>
		
	<tr>
		<td>6.6</td>
		<td><b>Faktor V-Haplotyp HR2</b>   A4070G</td>
	</tr>
		
	<tr>
		<td>6.7</td>
		<td><b>Faktor II</b>    G20210A</td>
	</tr>
		
	<tr>
		<td>6.8</td>
		<td><b>GPIa</b>   C807T</td>
	</tr>
		
	<tr>
		<td>6.9</td>
		<td><b>HPA-1 a/b</b>   (GPIIIa) Leu33Pro</td>
	</tr>
		
	<tr>
		<td>6.10</td>
		<td><b>PAI-1</b>  4G / 5G Polymorphismus</td>
	</tr>
		
	<tr>
		<td>6.11</td>
		<td><b>MTHFR</b>  A1298C / C677T</td>
	</tr>	
		
	<tr>
		<td>6.12</td>
		<td><b>ACE-Polymorphismus</b> Insertions/Deletions-Polymorphismus</td>
	</tr>	
	
		
	<tr bgcolor="CCCCCC">
		<td>7</td>
		<td colspan=2 class="text-grau">Pharmakogenetik</td>
	</tr>	
		
	<tr>
		<td>7.1</td>
		<td><b>CYP2C9*2 / CYP2C9*3</b>   Arg144Cys / Ile359Leu</td>
		<td rowspan=3>EDTA-Blut</td> 
	</tr>	
			
	<tr>
		<td>7.2</td>
		<td><b>MCYP2C19*2 / CYP2C19*3</b>   G681A / G636A</td>
	</tr>	
			
	<tr>
		<td>7.3</td>
		<td><b>VKORC1</b>   C1173T / G1639A</td>
	</tr>	
</table>
<br><br>

 [Stand 22.03.2012]





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